What service will give me the best travel deal for a flight + hotel + car from San Jose to San Diego?

Travelocity? Orbitz? Expedia? Something else.

I'm not willing to take just any hotel or flight. I want to be able to specifically pick from certain hotels and room types.

The best thing for you to do is check the prices on all of those you mentioned and see where you can get the best deal. You might also check out www.ytbtravel.com/WeWin. I've been able to help a few people find a good deal from this site. Have a good trip!