I want to travel from Seville to Murcia, can anyone inform me of the best way to get there?

Is your destiny Murcia city? (Murcia is a province, and is capital city has the same name)
By bus you can inform yourself here http://www.rumbo.es/
The bus starts from the "Estación del Prado" in Seville and arrives in "Estación de Autobuses" (Murcia's Bus Station) taking 7 hours aproximately to arrive in Murcia, and costs 36€ aproximately.
By train you can inform in http://www.renfe.es (choose the english version if your language is english). I don't if there is any direct train between the two cities, maybe you have to change trains in Madrid (Seville - Madrid and Madrid - Murcia) but I'm not sure.
By airplane: there are no direct flights from Seville to Murcia, so you have also to transfer, and I don't know how much it would cost.
Hope it helps

Fly its the best way but if you want to travel cheap thumb a lift or take the train.