When going to South Africa are there any necessary travel arrangements?

Vaccinations needed, specific visa, etc.

http://www.travel.state.gov/travel/cis_pa_tw/cis/cis_1008.html

Well make sure all your vacinations are in order, top your Tetanus, Polio drops, TB and Hepatitis A and B up, as well as Yellow Fever.

carry a gun with you.

Just ensure all your papers are in order and get visas and innoculations where needed.
Travel on official transport only and under NO CIRCUMSTANCES ride in minibus taxis. Call a Taxi Company to send you a proper licenced taxi.
Use the services of a licenced tour guide or company and pre-book your accommodation and tours.
EMail me for more info if you like.

Remember to pack a bodybag for the return journey and read this site before you go:
http://southafricanhell.blogspot.com/