Depends what you're into. If you like beaches check out Uraguay's Punte Del Este, it's the nicest beach I've ever been to.
Buenos Aires is a cool city, with nice architecture, cafe culture, and great steaks.
Santiago is also a nice city, with stunning views of the Andes on a clear day. Not sure you'll get much chance to go inland to the Andes, but if you do, checkout Bariloche in Argentina.
Also, I imagine the cruise ship will be going round cape horn, so take some sea-sickness pills. Check out the glaciers while you're down there to.
Have fun.
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