Did the Protestant Reformation cause more trade/travel with the Middle East?

Did Europe travel/trade more with the Middle East after the Protestant Reformation? My friend said they did but neither of us are history experts, if you know what I mean... ???

The protestant reformation caused lots of things expanded trade with the middle east sounds like a possible I mean at that time the trade links were dominated by the venetians and the middle east traded through venice also therefore it is a fair judgement to make although I would suggest it was more due to increased trade with other countries due to them already being protestant and therefore with the reformation trade links were obviously opened up and closed off from the catholic countries notably spain.