Is it safe to travel by bus in Mexico at night?

We are two female university students travelling from Mexico city to Palenque (in Chiapas) and then a small town on the coast neat Oaxaca. All the direct buses from mexico city to Palenque are night buses which leave in the evening and arrive in the morning, (~16 hours) do you think it is safe for us?

2 girls alone id say probably not.

You'll be fine. . . I did almost the same thing (from Mexico City to Oaxaca) last year, and I didn't have any problems. And I was all alone!

Yeah you'll be fine, most of the crimes happen at the border and not all over the country like many poeple think.
I've been in mexico many times, i studied there and lived for some months nothing bad happend to me. everybody was very nice to me.

Yes, if you grab your purses or put them below your feet when you sleep. The places that you will visit are peaceful and very reasonably safe.

Most people are tourist friendly, but don't push: if don't have to mention you're americans, don't do it.

Like many others here,I also think you will be just fine.On the late night buses it is not unusual to be stopped and boarded at random military checkpoints during the night.They usually just do a cursory search and you are on your way again in a few minutes.The only reason I mention it is that it can be a little disconcerting if you have never had it happen before and are not expecting it.
Buen Viaje!
jaun23

NOT AS SAFE IKNOW OF THREE PEOPLE THAT WERE ROBBED AT NIGHT. ONE JUST LAST YEAR.
NO HARM DONE AND THEY GOT $200.00

YOUR ODDS ARE 99% THAT YOU WILL BE FINE

Oh yes. just like May berry, only safer