Any risk to business if one travels to Cuba?

We are canadian and are getting married in Cuba in December. I have a lot of family in Panama that want to travel there as well. My uncle who is in Panama (no problems with Cuba or the US) now says he doesn't want to go because he is afraid the US will black list him for having travelled to Cuba and the business he does will the US will suffer. He doesn't want to risk this. Can this happen?
It's a direct flight to Cuba he is just afraid if they see that he visited Cuba as it would be stamped in his Passport it could hinder his work in the US.

Definitely no problem at all. Your uncle is not a US citizen and the US has no right to blacklist anyone who travels to Cuba...business or otherwise.
They just have issue with their own citizens travelling to Cuba. And it's not so much the travel as it is spending money in Cuba.

Your uncle, who is from Panama, will be fine and the US won't and cannot hinder his travels and business...nothing will suffer. In fact, many US citizens travel to Cuba for many different purposes and get travel licenses to go.
Cuba doesn't usually stamp passports either.
But either way, your uncle can go and enjoy your wedding! He can be worry-free.

The Cuban immigration services never stamps passports.
You have to buy a tourist visa at the (Cuban )
airport it's named tarjeta tourista ( tourist card) , it's a small card you have to fill in , the Cuban autorithies stamp this card
and you have to show it when you leave. After your trip you throw away this card , no one will know he stayed in Cuba.
Note that many US citizens ( an estimated 100,000) have travelled illegal to Cuba through Cancun or Toronto.

Havanalover
http://www.havana-guide.com

Cuba doesn't stamp passports.

I've been to Cuba three times and travel to the U.S. very often because I live so close to the border. No problems on either side

The US does not take any action against non-US citizens simply for travelling to Cuba on holiday.

(There have been a few cases of them black-listing non-US citizens who are involved in substantial business in Cuba - such as the directors of Sherritt. Any-one else - even those working in Cuba - have no problems.)