My preference would be a hotel in the Sukhumvit Road area not far from the Nana Skytrain stop. You can use the Skytrain to get you around town quick and easy.
From this Sukhumvit area you can walk to many restaurants, bars, travel agents, malls, street vendors and supermarkets.
You can find hotels in this same price range if you want but a hotel at half the price is still in the luxury level! Keep in mind that hotels with air, hot water, private toilet/shower, TV and maid service start around 600 baht (around $20 US.)
Landmark Hotel, Sheraton Grande, JW Marriott and the Amari Boulevard are a few hotels that you might want to check out.
Good luck.
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