What is the main travel route from Ghana, Africa to Puerto Rico?

airplanes.....American airlines travel to both places..

I don't think you could get a direct flight, but you could fly to the USA and then to PR

or

Fly to spain (madrid or barcelona) and then directly to PR from there.

You could probably do a search for conatiner ships that take passengers (I know some do) and get on one that is heading to San Juan (this is a major port on route to the Panama Canal)